Cathy Cavadini (39)

Blossom (voice)

Tara Strong (28)

Bubbles (voice)

E. G. Daily (39)

Buttercup (voice)

Tom Kenny (38)

Mayor / Snake / Lil' Arturo / Narrator (voice)

Tom Kane (38)

Professor Utonium / Him / Talking Dog (voice)

Roger L. Jackson (42)

Mojo Jojo (voice)

Jennifer Martin (29)

Ms. Sara Bellum (voice)

Jennifer Hale (29)

Ms. Keane / Princess Morbucks / Sedusa (voice)

Jim Cummings (48)

Fuzzy Lumpkins (voice)

Jeff Bennett (38)

Ace / Grubber / Big Billy (voice)

Chuck McCann (66)

The Amoeba Boys (voice)

Clancy Brown (42)

Mascumax (voice)

Rob Paulsen (45)

Dad / Little Utonium / Mr. Anoush / Junior / Schoolboy #1 (voice), Major Glory / E-Male (voice), Scientist / Brutus / Government Man #2 (voice)

Julie Nathanson (27)

Science Teacher / Schoolgirl #1 / Young Ms. Bellum (voice), Robin (voice)

Kevin Michael Richardson (36)

Shaquille Silverstein / Ya-Man / Announcer (voice), Alien Leader / Mailman / Government Man #3 (voice)