Lily Tomlin (55)

Ms. Frizzle (voice)

Daniel DeSanto (13)

Carlos (voice)

Stuart Stone (13)

Ralphie (voice)

Erica Luttrell (12)

Keesha (voice)

Lisa Yamanaka (11)

Wanda (voice)

Tara Meyer (17)

Dorothy Ann (voice)

Maia Filar (10)

Phoebe (voice)

Malcolm-Jamal Warner (24)

The Producer (voice)

Max Beckford (15)

Tim (voice)

Amos Crawley (13)

Arnold (voice) / Caller (voice) / Harry Arm (voice)

Carol Channing (73)

Cornelia C. Contralto II (voice)

Elliott Gould (56)

Mr. Perlstein (voice)

Dana Elcar (66)

Mr. Terese (voice)

Dom DeLuise (61)

Baker (voice)

Sherman Hemsley (56)

Mr. Junkett (voice)

Ed Asner (64)

Gen. Aranius (voice)

Tyne Daly (48)

Ralphie's Mom (voice) / Dr. Tennelli (voice)

Alex Trebek (54)

Announcer (voice)

Michael York (52)

Harry Herpst (voice)

Eartha Kitt (67)

Mrs. Franklin (voice)

Edward James Olmos (47)

Mr. Ramon (voice)

Robby Benson (38)

Archibald Seedplot (voice)

Ed Begley Jr. (44)

Logaway Larry (voice)

Matt Frewer (36)

Inspector 47 (voice)

Jessica Walter (53)

Ashlee Walker Club Dupree (voice)

Dolly Parton (48)

Katrina Eloise 'Murph' Murphy (voice)

Wynonna Judd (30)

Molly Cule (voice)

Paul Winfield (55)

Mr. Ruhle (voice)

Dabney Coleman (62)

Horace Scope (voice)

Bebe Neuwirth (35)

Flora Whiff (voice)