Frank Welker (44)

Tom / Jerry / McWolf (voice)

Don Messick (64)

Droopy (voice)

Charlie Adler (33)

Dripple (voice)

Richard Gautier (58)

Spike (voice)

Patric Zimmerman (35)

Tyke (voice)

Phil Hartman (41)

Calaboose Cal (voice)

Teresa Ganzel (33)

Miss Vavoom (voice)

Neil Ross (45)

Marvin (voice)

S. Scott Bullock (34)

Male Vermin Member #1 (voice)

Brian Cummings (42)

Clyde (voice) / El Gordo Gato (voice) / Fido (voice)

Danny Cooksey (14)

Male Vermin Member #2 (voice)

Arthur Burghardt (43)

Vavoom's Boyfriend (voice)

Paul Kreppel (43)

Beuregard (voice)

Sorrell Booke (60)

Wrestling Announcer (voice)

Townsend Coleman (36)

Knight (voice)

Tress MacNeille (39)

Cleocatra (voice) / Female Vermin Member (voice)

Kenneth Mars (55)

Narrator (voice)

Sally Struthers (43)

Jerry's Mother (voice)

Jo Anne Worley (53)

Witch (voice)

Hamilton Camp (55)

Tom's Grandfather (voice)

Kimmy Robertson (35)

Beach Girls (voice)

William Callaway (50)

Slowpoke Antonio (voice)

Pat Fraley (41)

Kyle (voice) / Tyrone the Tiny (voice) / The Yolker (voice) / Zebra (voice)

Kath Soucie (29)

Snookie (voice) / Toliver (voice) / Babysitter / Baby's Mother (voice) / Sugar-Belle (voice)

Brad Garrett (30)

Sir Butch-a-Lot (voice)

Greg Burson (41)

Chase School Teacher (voice)

David L. Lander (43)

Bernie the Bird (voice) / Kitten Chase Students (male) (voice)

Gary Owens (56)

Narrator (voice)

Jerry Houser (38)

Urfo (voice)

Jim Cummings (37)

Tundo the Elephant (voice) / Mandible Mangler (voice) / Dwayne the Dragon (voice) / Captain Redbeard (voice) / Mugger (voice)