Will Friedle (34)

Lion-O (voice) / Lion-O / Leo (voice)

Kevin Michael Richardson (46)

Panthro (voice) / Panthro / Anet (voice) / Panthro / Lynx-O / Lizard (voice) / Panthro / Avistan Guard (voice) / Panthro / Lizard (voice) / Panthro / Ancient Spirits of Evil (voice) / Panthro / Lizard / Bird Leader (voice) / Panthro / Sauro (voice) / Panthro / Mordax (voice) / Panthro / Sword Judge (voice) / Panthro / Anet / Avistan Pilot (voice)

Matthew Mercer (29)

Tygra (voice) / Tygra / Driller (voice) / Tygra / Kask (voice) / Tygra / Blind Swordsman (voice)

Emmanuelle Chriqui (35)

Cheetara (voice)

Madeleine Hall

WilyKit (voice)

Eamon Pirruccello (12)

WilyKat (voice)

Satomi Korogi (48)

Snarf (voice)

Larry Kenney (63)

King Claudus (voice)

Clancy Brown (52)

Grune (voice)

Robin Atkin Downes (34)

Mumm-Ra (voice) / Mumm-Ra / Addicus (voice) / Addicus / Lizard (voice) / Mumm-Ra / Capt. Koinelius Tunar (voice) / Javan (voice) / Mumm-Ra / Addicus / Avistan Guard (voice)

Corey Burton (55)

Jaga (voice) / Jaga / Tygus (voice) / Jaga / Jorma / Mob Leader (voice) / Jaga / Chef (voice) / Jorma (voice) / Jaga / Soldier (voice)

Dee Bradley Baker (48)

Slithe (voice) / Slithe / Kaynar (voice) / Rude Cat / Lizard #2 (voice) / Slithe / Kaynar / Ro-Bear-Bill (voice) / Slithe / Kaynar / Ro-Bear-Bill / Avistan Pilot (voice) / Sentry / Lizard (voice) / Ro-Bear-Bill / Berbils / Trollog (voice) / Slithe / Petalar / Old Petalar (voice) / Slithe / Kaynar / Rat (voice)

Pamela Adlon (45)

Pumyra (voice) / Pumyra / Wolo Mother (voice)

Cree Summer (42)

Panthera (voice) / Gusto (voice)

Michael McKean (63)

Vultaire (voice)

Hynden Walch (40)

Jonto (voice)

Pat Musick (55)

Aldo (voice)

Fred Tatasciore (43)

Tookit / Dog (voice) / Dodo (voice) / Dodo / Tookit (voice)

Jason Marsden (36)

Leo (voice)

Carlo Rota (50)

Ratar-O (voice)

Chris Anthony Lansdowne

Mama (voice)

John Pirruccello

Papa (voice)

Jim Meskimen (51)

Aburn (voice) / Dog Constable (voice) / Ponzi (voice) / Vendor (voice)

Jim Cummings (58)

Caspin / Ancient Spirits of Evil (voice)

Juliet Landau (46)

Queen Leona (voice)

Tara Strong (38)

Young Lion-O (voice)

Grey DeLisle (37)

Young Cheetara (voice)

Richard Chamberlain (77)

Zigg (voice)

Héctor Elizondo (74)

Viragor (voice)

Jon Polito (60)

Conquedor (voice)