"Break 50" is a YouTube series hosted by professional golfer Bryson DeChambeau, where he and a guest attempt to shoot a score of 49 or less (sub-50) in a two-person scramble format, playing from the forward tees. The series features various guests, including fellow golfers, athletes, and even public figures like President Donald Trump. The challenge highlights the difficulty of achieving such a low score, even with the advantages of a scramble and forward tees.