George O'Hanlon (49)

George Jetson (voice)

Penny Singleton (54)

Jane Jetson (voice)

Daws Butler (45)

Elroy Jetson (voice)

Janet Waldo (43)

Judy Jetson (voice)

Jean Vander Pyl (42)

Rosie (voice)

Don Messick (36)

Astro (voice)

Mel Blanc (54)

Cosmo S. Spacely (voice)

Frank Welker (16)

Orbitty (voice)

Foster Brooks (50)

(voice)

Howard Morris (43)

Harlan (voice) / Montague Jetson (voice) / Mr. Tweeter (voice) / Emcee (voice) / Jet Screamer (voice) / Bus Driver (voice) / Boppo Crushstar / CB (voice) / Nimbus the Great / George's Conscience / Willie (voice)

Allan Melvin (39)

Mangler Mars (voice) / Mr. Spendwell / Construction Worker (voice) / Jacob Marsley / Ghost of Christmas Present (voice) / Solareenie (voice)

Shepard Menken (40)

(voice) / Nimbly (voice) / Mugsy Megatron / Microbe (voice)

Dick Beals (35)

Arthur Spacely (voice) (uncredited) / (voice) / Arthur Spacely (voice)

John Stephenson (39)

Gary Gammaray (voice) / Dr. Scarem (voice) / Commissioner / DWMR Officer (voice)

Barry Gordon (13)

Tiny Terror / Betting Machine (voice) / Mechanic (voice) / Sneak (voice)

Hal Smith (46)

(voice) / Beta Ranch Manager (voice)

Joan Gardner (35)

Helen (voice) (uncredited) / (voice)

Selma Diamond (42)

Di-Di (voice)

Frank Nelson (51)

Robot Dance Instructor (voice) / Ralph (voice)

Sonny Melendrez

Gus Guesser - Game Show Host (voice) / Mr. Rocket (voice)

Brenda Vaccaro (22)

Di-Di (voice)

Paul Winchell (39)

Dr. Input (voice)

B.J. Ward (18)

Robot / Wicked Wrench of the West (voice)

Bea Benaderet (56)

Emily Scopes / Celeste Skyler (voice)

Didi Conn (11)

Cousin Melissa (voice)

Dave Coulier (3)

Robot Umpire (voice)

René Auberjonois (22)

(voice)

Phil Hartman (13)

School Patrol Robots / Executive Vice President (voice)

Nancy Cartwright (4)

Asteroid Cogswell (voice)

William Windom (38)

Saturn Cyclops (voice)