Ryan Colt Levy (38)

Lead Soldier Thief / Radio Host / Agency Head (voice)

Imari Williams

General / Fake Demon Hunter / Host (voice)

Sunkrish Bala (40)

King (voice)

Zeke Alton

Dr. Fisher / Kurt / Chuck (voice) / Dr. Fisher (voice) / Dr. Fisher / Soldier Thief #2 / Demon (voice)

Tina Majorino (40)

Sentry (voice)

Tyson Smith (41)

Sly (voice)

Jason E. Kelley

Bruce / Arnold (voice)

Leilani Barrett

Patriot (voice) / Patriot / Cop / Soldier

Benjamin Abiola

Anders (voice) / Anders / Guard (voice) / Anders / Soldier Thief #1 (voice)

Johnny Yong Bosch (49)

Dante (voice) / Dante / Mercenary #01 (voice) / Dante / Soldier #1 (voice) / Dante / Boy (voice)

Ian James Corlett (62)

Baines (voice)

Fryda Wolff (42)

Ninja / Demon Woman (voice) / Ninja (voice) / Ninja / Cop (voice)

Chris Coppola (56)

Enzo (voice) / Enzo / Mercenary #03 (voice) / Enzo / Frat Boy (voice) / Enzo / Officer / Man (voice)

Jon Gries (67)

Pres. Hopper / Late Night Host (voice) / Pres. Hopper / Soldier (voice)

Matthew Waterson

News Anchor / Senator / Priest (voice) / Large Soldier (voice)

Hoon Lee (51)

White Rabbit (voice) / White Rabbit / Pilot (voice) / White Rabbit / Soldier #2 (voice) / White Rabbit / News Anchor (voice) / White Rabbit / Horned Demon (voice)

Kevin Conroy (69)

Baines (voice) / Baines / Mercenary #02 (voice) / Baines / Soldier #3 (voice) / Baines / Demon Soldier (voice) / Baines / Passerby (voice)

Evie Hsu

Young Mary (voice)

Roger L. Jackson (66)

Plasma / Griff (voice) / Officer / Interrogator (voice) / Demon Hunter #1 / Plasma (voice) / Additional Voices (voice)

Kari Wahlgren (47)

Eva (voice) / Echidna / Demon Girl / Eva (voice) / Eva / Echidna (voice) / Echidna (voice) / Additional Voices (voice)

Erica Lindbeck (32)

Kalina (voice) / Mother / Baby / Demon Kid (voice) / Woman / Demon Refugee (voice) / Mother / News Anchor / Waitress (voice)

Kue Lawrence (13)

Young Dante (voice)

Scout Taylor-Compton (36)

Mary (voice) / Mary / Additional Voices (voice)

Marcel Nahapetian

Young Vergil (voice)

Ray Chase (37)

Arkham / Agni / Rudra (voice) / Rudra / Demon Soldier (voice)

Robbie Daymond (43)

Vergil (voice) / Knight (voice)

Jason Marnocha (36)

Cavaliere / Demon Man (voice) / Cavaliere / Demon (voice) / Cavaliere / Sergeant / Demon Man (voice) / Cavaliere (voice) / Civilian / Predator Demon (voice)

Dee Bradley Baker (62)

Predator Demon (voice)

Sa'Raya Paris Johnson (10)

Additional Voices (voice)

Donovan Patton (47)

Bloodstryke / Demon (voice)