Debi Derryberry (41)

Jimmy Neutron (voice)

Andrea Martin (55)

Ms. Fowl / Lady (voice)

Jeffrey Garcia (27)

Sheen Estevez (voice)

Rob Paulsen (46)

Carl Wheezer (voice)

James Sie (39)

You Yee / Elderly Monk / Ninja (voice)

Peter Frampton (52)

Hugh Neutron (singing voice)

Ming-Na Wen (38)

Peggy Tsu (voice)

Tom Kane (40)

Dean Cain (voice)

Wendie Malick (51)

Beautiful Gorgeous (voice)

Christian Slater (32)

Jet Fusion (voice)

Jim Meskimen (42)

Quentin Smithee (voice)

Michael Clarke Duncan (44)

Commander Baker (voice)

Ben Stein (57)

Giggles the Clown (voice)

Mel Brooks (76)

Santa Claus (voice)

Phyllis Diller (85)

Granny Neutron (voice)

Neil Ross (57)

Announcer (voice)

Grey DeLisle (28)

Elke (voice) / Mombot (voice) / Sally (voice)

John Kassir (44)

Seymour / Student #3 (voice)

Tress MacNeille (51)

Annabelle / Aunt Kari / Great Aunt Amanda (voice)

Bill Farmer (49)

Buford / Reporter (voice)

Corey Burton (46)

Dr. Dark / Pizza Monster (voice) / Rayburn (voice) / Spamdini (voice) / Head Monk (voice)

Maurice LaMarche (44)

Zix / Ticket Taker (voice) / Zix / Tee / Reporter (voice) / Goddard Digital Voice (voice)

Michael Hagiwara (45)

Japanese Announcer (voice) / Master Hong / Ninja (voice)

Joe Lala (54)

Mr. Estevez (voice)

Charlie Adler (45)

Junkman (voice)

Jim Cummings (49)

Ultra Lord (voice) / Mayor / Dog (voice) / Martian #3 (voice) / Mayor (voice) / Captain Betty / Mayor (voice) / Atila (voice) / Popbot / Gortox / Goddard Speaking (voice)

Jeff Bennett (39)

Travoltron/Barbarino (voice) / Dr. Moist / Announcer (voice) / Positive Jimmy / Negative Jimmy / Macho Jimmy (voice) / Travoltron / Newscaster / Salesman (voice)

Tom Kenny (40)

Nanobot #2 (voice) / Copbot / Interviewer (voice) / Max / Wilderman / Mr. Moodini (voice) / WL3000 (voice)

Billy West (50)

Sam Melnick (voice) / Sam Melnick / Corky Shimatzu / Lars (voice) / Sam Melnick / Lou / Reporter (voice) / Corky Shimatzu / Larry Llama (voice) / TV Newscaster / Lucky Joe (voice) / Sam Melnick / Lance (voice) / Sam Melnick / Corky Shimatzu (voice) / Sam Melnick / Corky Shimatzu / Kid (voice) / Corky Shimatzu (voice) / Sam Melnick / Pilot (voice) / Sam Melnick / Man (voice) / Sam Melnick / Blix (voice) / Blix (voice)

Kath Soucie (41)

Betty Quinlan (voice)