Born just after the turn of the century in Louisiana, Mantan began running away from home at age 12 to join circuses and medicine shows, only to be brought back time and again. During these times he sharpened his comic skills and developed routines and acts that eventually became popular on the vaudeville stage, or what was then called the "chitlin' circuit." A solo performer by nature, he often teamed up with other famous comics (such as Ben Carter) to keep working, and became a deft performer of "indefinite talk" routines, where two quicksilver comics continually topped each other in mid-sentence, as if reading each other's mind (i.e., "Say, did you see...?" "Saw him just yesterday...didn't look so good"). Mantan's focus gradually shifted his trade toward film, where he initially appeared in servile bits (shoeshine men, porters, waiters). However, his talent for making people laugh couldn't be overlooked and he soon earned featured status in Harlem-styled western parodies and grade "A" comedy films playing the superstitious, ever-terrified manservant running from any kind of impending doom.