Grand-daughter of Indian freedom fighter, lawyer, and former Justice Rajni Patel, Amisha, a Gemini, was born in Bombay's Breach Candy Hospital. She is nicknamed Angel and Princess. Her younger brother Ashmit Patel is also a Bollywood film actor and her name is a blend of the first three letters of her father's name Amit and the last three letters of her mother's name Asha.