Berlinski received his Ph.D. in philosophy from Princeton University and was later a postdoctoral fellow in mathematics and molecular biology at Columbia University. He has authored works on systems analysis, differential topology, theoretical biology, analytic philosophy, and the philosophy of mathematics, as well as three novels. He has also taught philosophy, mathematics and English at Stanford, Rutgers, the City University of New York and the Université de Paris. In addition, he has held research fellowships at the International Institute for Applied Systems Analysis in Austria and the Institut des Hautes Études Scientifiques.