Zhang Ming'en graduated from the prestigious Central Academy of Drama. During his school and early college days, he participated in some short films and a sitcom's bit part before officially debuting in 2016 with a memorable role as Adjutant Zhang Rishan in the tomb-raiding series The Mystic Nine. He went on to star in a spin-off of the series titled Tiger Bones Plum Blossom, which focuses on his character.[3] In 2017, he acted in a highly acclaimed mystery fantasy web drama, Tientsin Mystic. In 2018, Zhang reprised his role in the spin-off to The Mystic Nine, Tomb of the Sea. His performance was well-received by viewers and received acclaim. He was cast as the male protagonist for the first time in the romance supernatural drama, Destiny's Love.