Mohammad-Reza Lotfi (Persian: محمدرضا لطفی‎; 1 January 1947 – 2 May 2014) was an Iranian classical musician renowned for his mastery of the tar and setar. He collaborated with singers such as Mohammad-Rezā Shajarian, Hengameh Akhavanو Shahram Nazeri and Alireza Shahmohammadi.