Potamkin is known for founding Perpetual Motion Pictures (later called Buzzco Associates) with Candy Kugel and Vincent Cafarelli in 1968, which led to the production of hundreds of television advertisements, including the Hawaiian Punch series, MTV's "Top of the Hour" (the moon man), and MTV's "I Want My MTV" campaign. He also established the companies Visionary Media, Project X, and Southern Star Productions, an Australian/American subsidiary of Hanna-Barbera. Potamkin produced the animated specials The Berenstain Bears' Christmas Tree in 1979 and Cartoon All-Stars to the Rescue in 1990, among others.