Roberto Benigni (51)

Roberto (segment "Strange to Meet You")

Steven Wright (48)

Steven (segment "Strange to Meet You")

Joie Lee (41)

Good Twin (segment "Twins")

Cinqué Lee

Evil Twin (segment "Twins") / Kitchen Guy (segment "Jack...")

Steve Buscemi (46)

Danny (segment "Twins")

Iggy Pop (56)

Iggy (segment "Somewhere in California")

Tom Waits (54)

Tom (segment "Somewhere in California")

Joseph Rigano (71)

Joe (segment "Those Things'll Kill Ya")

Vinny Vella (57)

Vinny (segment "Those Things'll Kill Ya")

Vinny Vella, Jr.

Vinny Jr. (segment "Those Things'll Kill Ya")

Renée French

Renée (segment "Renée")

E.J. Rodriguez

Waiter (segment "Renée")

Alex Descas (46)

Alex (segment "No Problem")

Isaach de Bankolé (46)

Isaach (segment "No Problem")

Cate Blanchett (34)

Cate / Shelly (segment "Cousins")

Michael Hogan

Waiter (segment "Cousins")

Jack White (28)

Jack (segment "Jack Shows Meg His Tesla Coil")

Meg White (29)

Meg (segment "Jack Shows Meg His Tesla Coil")

Alfred Molina (50)

Alfred (segment "Cousins?")

Steve Coogan (38)

Steve (segment "Cousins?")

Katy Hansz

Katy (segment "Cousins?")

GZA (37)

GZA (segment "Delirium")

RZA (34)

RZA (segment "Delirium")

Bill Murray (53)

Bill Murray (segment "Delirium")

William Rice (72)

Bill (segment "Champagne")

Taylor Mead (79)

Taylor (segment "Champagne")