Set in 1960s Mexico at a girls' boarding school, Luisa, María, and Otilia, a trio of women, decide to break all the rules and put what they learned in school—being good wives and mothers—into practice. So, they decide to leave school for 20 days (the time until their graduation) and embark on a journey that will take them through various adventurous and fun situations. Among them, a gang encounter and three handsome cowboys will leave "Las Tres Coquetonas" learning about their own experiences, as well as about how to find true love.