Keanu Reeves (38)

Neo ("Kid's Story") (voice)

Carrie-Anne Moss (35)

Trinity ("Kid's Story" and "A Detective Story") (voice)

Clayton Watson (26)

The Kid ("Kid's Story") (voice)

Pamela Adlon (36)

Jue ("Final Flight of the Osiris") / Manabu ("Beyond") (voice)

Melinda Clarke (34)

Alexa ("Matriculated") (voice)

John DiMaggio (34)

Crew Man ("Final Flight of the Osiris") / Kaiser ("Program") (voice)

Kevin Michael Richardson (38)

Thadeus ("Final Flight of Osiris") / Cop ("Kid's Story") / Agent #2 ("World Record")

Tom Kenny (40)

Operator ("Final Flight of Osiris")

Rick Gomez (30)

Pilot ("Final Flight of Osiris")

Tara Strong (30)

Crew Woman ("Final Flight of Osiris") / Nurse ("World Record") / Misha ("Beyond")

Bette Ford (75)

Old Woman ("Final Flight of Osiris")

Julia Fletcher (46)

The Instructor ("The Second Renaissance Part I & II") / Narrator ("World Record")

Dane A. Davis

01 Versatran Spokesman ("The Second Renaissance Part I & II")

Debi Derryberry (42)

Kid ("The Second Renaissance Part I & II")

Jill Talley (40)

Mother ("The Second Renaissance Part I & II")

Dwight Schultz (55)

Additional Voices ("The Second Renaissance Part I & II") / Monaka ("Matriculated")

James Arnold Taylor (33)

Additional Voices ("The Second Renaissance Part I & II") / Ash ("A Detective Story") / Raul ("Matriculated")

John DeMita (44)

Teacher ("Kid's Story")

Hedy Burress (29)

Cis ("Program") / Yoko ("Beyond")

Phil LaMarr (36)

Duo ("Program")

Victor Williams (32)

Dan ("World Record")

John Wesley (55)

Dan's Dad ("World Record")

Alex Fernandez (35)

Tom ("World Record")

Allison Smith (33)

Reporter ("World Record")

Matt McKenzie (30)

Agent #1 ("World Record") / Agent ("Beyond") / Agent ("A Detective Story")

Tress MacNeille (51)

Housewife ("Beyond") / Kenny ("Beyond")

Kath Soucie (42)

Pudgy ("Beyond") / Masa ("Beyond") / Sara ("Beyond")

Terrence 'T.C.' Carson (44)

Clarence ("A Detective Story")

Rodney Saulsberry (46)

Chyron ("Matriculated")

Olivia D'Abo (34)

Rox ("Matriculated")