After Dr. Pepe Freeman and Arthur Fistington have been lost on Meme Island, a research team from Memesford University has been sent to recover their research, including the Dankest Meme. Mike Dankwood, Cory Doger, and Gabe "Harambe" Ahmed are on the hunt, and must face the trials of meme island, including the forest of overused memes, the champ, and the guardian of the Dank Bridge.