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110 cast members and 165 crew members
Lauren K. Robek
Susan / Pie Mom (as Kirsten Robek)
Sean Hayes
Mr. Tinkles (voice)
Joe Pantoliano
Peek (voice)
Michael Clarke Duncan
Sam (voice)
James Marsden
Diggs (voice)
Jeff Goldblum
Professor Brody
Melissa Rauch
Gwen the Cat (voice)
Nick Nolte
Butch (voice)
Elizabeth Perkins
Mrs. Brody
Max Greenfield
Roger the Dog (voice)
George López
Pablo the Parrot (voice)
Christina Applegate
Catherine (voice)
Alexander Pollock
Scotty Brody
Bette Midler
Kitty Galore (voice)
Miriam Margolyes
Sophie the Castle Maid
Callum Seagram Airlie
Max
Tobey Maguire
Lou the Beagle (voice)
Pascale Hutton
Jackie
Sarah Giles
Zoe
Alec Baldwin
Katt Williams
Seamus (voice)
Neil Patrick Harris
Lou (voice)
John Murphy
Ollie
Susan Sarandon
Ivy (voice)
Paul Dobson
Zeke (voice)
Wallace Shawn
Calico (voice)
Garry Chalk
Old Ed (voice)
Roger Moore
Tab Lazenby (voice)
Michael Daingerfield
Duke (voice)
Jon Lovitz
Michael Meneer
News Reporter
Charlton Heston
The Mastiff (voice)
Andy Thompson
Paw Street Market Manager
Chris O'Donnell
Shane
Glenn Ficarra
Russian Blue (voice)
Matt Afonso
Slacker Employee
Jack McBrayer
Chuck
Billy West
Ninja Cat #1 (voice) / Ninja Cat (voice)
James Rha
Veterinarian
John Michael Higgins
Ginger Kitten (voice)
